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Point of Care Reagent Blisters FAQs


What design services do you offer for reagent blisters?

J-Pac Medical offers a full range of design services to provide you with a turnkey solution for microfluidic reagent blisters and consumables. We work closely with you to understand the technical requirements for burst strength, activation, and other critical parameters and design a blister and manufacturing process based on those inputs. We are an FDA Registered, ISO 13485:2016 certified company with extensive expertise in blister design, material selection, and manufacturing. Other services include rapid prototyping, 3D modeling, Design of Experiments, Accelerated Shelf Life Testing, and Validation.

Can we get blister samples?

Yes. J-Pac has developed off-the-shelf samples that are an affordable and timely solution for up-front development. J-Pac offers several types of samples for purchase.

What materials do you offer?

We select materials based on the specific needs for reagent chemistry. For most applications, a multi-layered foil material is used that consists of a lidding foil and forming foil.

Blister Activation

What is the force required to actuate a blister?

The force required to activate a microfluidic reagent blister is dependent on the actuation mechanism (e.g. lance, manual compression, etc). A general guideline is 30N +/- 15N.

How do you actuate a blister?

We have experience in many actuation methods. Common approaches include lancing, mechanical compression, and rolling.


What amount of fluid is recovered from the blister?

The amount of fluid recovered varies by the actuation and recovery method. A rule of thumb is 90% for common blister actuation methods.

What volumes can be filled?

Microfluidic reagent filling is custom to the application. A general range is between 30-1,000 ?L.

Can you perform low oxygen filling?

We have microfluidic reagent blister filling technology that can achieve both 100% fill as well as extremely low O2 levels - less than 2% on average.

What is a common fill ratio?

lab-on-a-chip reagent blister fill ratio of 80% full is common, resulting in a headspace ratio of 20%. J-Pac can also provide microfluidic reagent blisters with 100% fill (i.e. zero head space).


How do you mount the blisters?

Blisters are typically mounted using a pressure sensitive tape that is custom fit to the microfluidic cartridge.


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